The Benadryl Challenge: Why OTC Drugs Aren't Always Safe

Even though antihistamines like Benadryl (diphenhydramine) are available over-the-counter (OTC), that doesn’t mean they’re risk-free. Benadryl abuse among teens ages 13 to 19 is on the rise according to America's Poison Centers. So far over 7,000 cases of Benadryl exposure were reported to poison centers in 2026, with nearly 14% considered intentional abuse. This has dramatically increased over the past 6 years. The dangerous social media trend known as the “Benadryl Challenge” began in 2020. Unfortunately, it has recently resurfaced across the U.S. The challenge involves taking large amounts of Benadryl. Taking too much Benadryl is dangerous. It can cause a variety of side effects including hallucinations, loss of consciousness, and seizures. Teens have ended up in the hospital and have also died from this dangerous challenge. Families and caregivers should talk with their kids and teens about the dangers of misusing Benadryl. The OTC product Zzzquil contains the same active ingredient as Benadryl: diphenhydramine. It’s marketed for sleep, but it can cause the same side effects as Benadryl. Always read the Drug Facts label on the package before taking OTC Benadryl products, for dosing instructions. Your pharmacist and prescribing clinician are great resources too. If you or a loved one takes too much Benadryl, call the poison control center right away at 1-800-222-1222. This is a 24/7 hotline staffed with clinicians, and your call remains confidential. But call 911 first if someone is unconscious, experiencing a seizure, or having trouble breathing. Medication safety is key when it comes to preventing Benadryl abuse. It’s best to keep Benadryl and all medications out of reach of kids, preferably locked away on a high shelf. As a summer travel tip, avoid giving children Benadryl to help them sleep. It's not an approved use, and it can cause dangerous side effects.